Genetic Profiling

“Gene expression profiling is an attempt to characterize the activity of genes,” says Suzanne Vernon, Ph.D., of the Center for Disease Control (CDC) in Atlanta, GA.  “You have your DNA and the genes are active; they express messages and one can correlate that activity with patterns or processes.  At any one time, about 30,000 genes [...]

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Tying Up Loose Ends

At the beginning of this article, we mentioned that the AACFS was combining CFS with FM as part of its educational mission.  Debra Buchwald, M.D., and co-workers conducted a large research project to evaluate the symptoms commonly reported by each condition and determine the degree to which they may, or may not, be related.  What [...]

Infectious Agents

Could CFS be caused by an unresolved, ongoing viral infection?  Early reports in the medical journals assumed this was the case, but John Hay, Ph.D., went through a long list of potential infectious candidates at the meeting, and concluded that “none of the agents proved to be the cause.”  A recent report looking for evidence [...]

Immune Dysfunction

The AVP, oxidative stress, and an over-production of NO may all be related to immune system problems.  In fact, Suhadolnik commented in his speech that while NO is supposed to activate natural killer (NK) cells (the immune system’s front line defense mechanism), this may be impaired in patients with CFS.  “This is one of the [...]

Nitric Oxide (NO)

Another theory, mentioned by several speakers at the conference, relates to elevated levels of nitric oxide (NO).  It’s a theory that has been put forth by Martin Pall, Ph.D., of Washington State University in Pullman, WA.  The formation of NO is triggered by pro-inflammatory cytokines, the same substances that activate the Anti-Viral Pathway.  NO goes [...]

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Oxidative Stress

What is oxidative stress?  It is a situation that can occur in the tissues when certain highly reactive chemicals (called free radicals) are generated and the body doesn’t produce enough defense-type substances to counterbalance the free radicals.  This can cause damage to cell membranes and other structures in the body.  The damage may be subtle [...]

Organica Research


AVP Defect and Function

Suhadolnik described a study in which he looked at the connection between this abnormal RNase L enzyme in 67 CFS patients, 60 healthy individuals, and 52 depressed people.  The presence of the 37-kDa enzyme plus a few other immune parameters could distinguish the CFS patients from the healthy controls and depressed patients.  With regards to [...]